[CAS NO. 173334-57-1] Aliskiren

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Catalog:	SLK-S5767
Brand:	Selleck
CAS:	173334-57-1

Overview

MDL	MFCD09839018
Molecular Weight	551.76
Molecular Formula	C30H53N3O6
SMILES	O(CCCOC)C1=C(OC)C=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C(N)=O)(C)C)=O)[C@H](C)C)O)N)[C@H](C)C)=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8124 mL	9.0619 mL	18.1238 mL
5 mM	0.3625 mL	1.8124 mL	3.6248 mL
10 mM	0.1812 mL	0.9062 mL	1.8124 mL
50 mM	0.0362 mL	0.1812 mL	0.3625 mL

Description

Aliskiren(CGP 60536) is a inhibitor with antihypertensive activity.

Targets

Renin ^[1]

In vitro

Aliskiren is the fourth class of pharmacological agents that modify the function of RAAS. It is an octanamide, is the first known representative of a new class of completely nonpeptide, low-molecular-weight, orally active transition-state renin inhibitors. Aliskiren has good water solubility and low lipophilicity, and is resistant to biodegradation by peptidases in the intestine, blood circulation, and the liver. Aliskiren has 10,000-fold higher affinity for renin than for other aspartic peptidases.

References

[1] Pranay Wal, et al. J Pharm Bioallied Sci. 2011, 3(2): 189–193.

Synonyms

Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-

Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, [αS-(αR*,γR*,δR*,ζR*)]-

(αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide

CGP 60536

Aliskiren

CGP60536B

SPP 100

Tekturna

Rasilez

(2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide

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