[CAS NO. 1223403-58-4]  Larotrectinib

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PRODUCTS SPECIFICATIONS [1223403-58-4]

Distributor
Catalog
SLK-S5860
Brand
Selleck
CAS
1223403-58-4

DESCRIPTION [1223403-58-4]

Overview

MDLMFCD28902192
Molecular Weight428.44
Molecular FormulaC21H22F2N6O2
SMILESFC1=C([C@@]2(N(CCC2)C3=NC4=C(NC(=O)N5CC[C@H](O)C5)C=NN4C=C3)[H])C=C(F)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.3340 mL11.6702 mL23.3405 mL
5 mM0.4668 mL2.3340 mL4.6681 mL
10 mM0.2334 mL1.1670 mL2.3340 mL
50 mM0.0467 mL0.2334 mL0.4668 mL

Description

Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is an ATP-competitive, oral administered and highly selective inhibitor of the .

Targets

TRK [1]


Synonyms

1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-
(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide
ARRY 470
LOXO 101
Larotrectinib