[CAS NO. 1784282-12-7] KHS101 hydrochloride
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PRODUCTS SPECIFICATIONS [1784282-12-7]
Catalog
SLK-S5919
Brand
Selleck
CAS
1784282-12-7
DESCRIPTION [1784282-12-7]
Overview
| MDL | MFCD28133379 |
|---|---|
| Molecular Weight | 375.92 |
| Molecular Formula | C18H22ClN5S |
| SMILES | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
KHS101 is a small-molecule inhibitor of , which is a key component of centrosome-microtubule dynamic networks.
Targets
| TACC3 [1] |
In vitro
In two intracranial patient-derived xenograft tumor models in mice (glioblastoma multiforme and neural progenitor cell models), systemic administration of KHS101 reduced tumor growth and increased survival without discernible side effects. KHS101 crosses the blood-brain barrier (BBB) and selectively induces neuronal differentiation of hippocampal neural progenitor cells in vitro and in vivo. KHS101 treatment increases survival of glioblastoma multiforme xenograft tumor-bearing mice.
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