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Catalog:
SLK-S6078
Brand:
Selleck
CAS:
1803605-68-6
Overview
MDL
MFCD28145281
Molecular Weight
291.84
Molecular Formula
C12H22ClN3OS
SMILES
O=C(NC1CCCCCC1)CSC2=NCCN2.[H]Cl
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.4265 mL
17.1327 mL
34.2654 mL
5 mM
0.6853 mL
3.4265 mL
6.8531 mL
10 mM
0.3427 mL
1.7133 mL
3.4265 mL
50 mM
0.0685 mL
0.3427 mL
0.6853 mL
Description
ICCB-19 hydrochloride is an inhibitor of with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits . ICCB-19 effectively induces .
ICCB-19 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
