[CAS NO. 1803605-68-6] ICCB-19 hydrochloride
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PRODUCTS SPECIFICATIONS [1803605-68-6]
Catalog
SLK-S6078
Brand
Selleck
CAS
1803605-68-6
DESCRIPTION [1803605-68-6]
Overview
| MDL | MFCD28145281 |
|---|---|
| Molecular Weight | 291.84 |
| Molecular Formula | C12H22ClN3OS |
| SMILES | O=C(NC1CCCCCC1)CSC2=NCCN2.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4265 mL | 17.1327 mL | 34.2654 mL |
| 5 mM | 0.6853 mL | 3.4265 mL | 6.8531 mL |
| 10 mM | 0.3427 mL | 1.7133 mL | 3.4265 mL |
| 50 mM | 0.0685 mL | 0.3427 mL | 0.6853 mL |
Description
ICCB-19 hydrochloride is an inhibitor of with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits . ICCB-19 effectively induces .
In vitro
ICCB-19 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
References
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