[CAS NO. 947303-87-9] PF 429242

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PRODUCTS SPECIFICATIONS [947303-87-9]

Catalog

SLK-S6418

Brand

Selleck

CAS

947303-87-9

DESCRIPTION [947303-87-9]

Overview

MDL	MFCD21603814
Molecular Weight	409.56
Molecular Formula	C25H35N3O2
SMILES	O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4416 mL	12.2082 mL	24.4164 mL
5 mM	0.4883 mL	2.4416 mL	4.8833 mL
10 mM	0.2442 mL	1.2208 mL	2.4416 mL
50 mM	0.0488 mL	0.2442 mL	0.4883 mL

Description

PF 429242 is known as a inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).

Targets

S1P ^[1]
(Cell-free assay)

170 nM

In vitro

In cultured human liver (Hep-G2) cells, PF-429242 prevents proteolytic processing and nuclear translocation of SREBP, reduces the expression of key genes involved in cholesterol synthesis and fatty acid synthesis, and inhibits both pathways in the absence of any cytotoxicity. The addition of PF-429242 suppresses the viral propagation of all serotypes of DENV in several primate-derived cells.

References

[1] Bruce A Hay, et al. Bioorg Med Chem Lett . 2007 Aug 15;17(16):4411-4.
[2] Leo Uchida, et al. Viruses . 2016 Feb 10;8(2):46.