[CAS NO. 1802326-66-4] JNJ 63533054
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PRODUCTS SPECIFICATIONS [1802326-66-4]
Catalog
SLK-S6425
Brand
Selleck
CAS
1802326-66-4
DESCRIPTION [1802326-66-4]
Overview
| MDL | MFCD29924732 |
|---|---|
| Molecular Weight | 316.78 |
| Molecular Formula | C17H17ClN2O2 |
| SMILES | O=C(NCC(N[C@H](C1=CC=CC=C1)C)=O)C2=CC=CC(Cl)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1568 mL | 15.7838 mL | 31.5676 mL |
| 5 mM | 0.6314 mL | 3.1568 mL | 6.3135 mL |
| 10 mM | 0.3157 mL | 1.5784 mL | 3.1568 mL |
| 50 mM | 0.0631 mL | 0.3157 mL | 0.6314 mL |
Description
JNJ 63533054 is a potent and selective agonist. It specifically activated human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays.
Targets
In vitro
JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM).
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