[CAS NO. 168425-64-7]  Compound 401

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PRODUCTS SPECIFICATIONS [168425-64-7]

Store
Catalog
SLK-S6506
Brand
Selleck
CAS
168425-64-7

DESCRIPTION [168425-64-7]

Overview

MDLMFCD10568147
Molecular Weight281.31
Molecular FormulaC16H15N3O2
SMILESO=C1C=C(N2CCOCC2)N=C3N1C=CC4=C3C=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM3.5548 mL17.7740 mL35.5480 mL
5 mM0.7110 mL3.5548 mL7.1096 mL
10 mM0.3555 mL1.7774 mL3.5548 mL
50 mM---

Description

Compound 401 is a synthetic inhibitor of (IC50=0.28 μM) and (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.

Targets

DNA-PK [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
0.28 μM5.3 μM