[CAS NO. 1104874-94-3] Defensamide (MHP)

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PRODUCTS SPECIFICATIONS [1104874-94-3]

Catalog

SLK-S6512

Brand

Selleck

CAS

1104874-94-3

DESCRIPTION [1104874-94-3]

Overview

MDL	MFCD31382170
Molecular Weight	293.36
Molecular Formula	C16H23NO4
SMILES	OC(C=C1)=CC=C1C[C@@H](C(OC)=O)NC(CCCCC)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.4088 mL	17.0439 mL	34.0878 mL
5 mM	0.6818 mL	3.4088 mL	6.8176 mL
10 mM	0.3409 mL	1.7044 mL	3.4088 mL
50 mM	0.0682 mL	0.3409 mL	0.6818 mL

Description

Defensamide (MHP) is an activator of . It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.

Targets

SPHK1 ^[1]

In vitro

Treatment with MHP directly activates SPHK1 and increases cellular S1P content in normal cultured human keratinocytes. MHP also stimulates CAMP production and enhances epidermal antimicrobial defense via the recently identified S1P-dependent mechanism. Defensamide (MHP) treatment also activates NF-κB which is assessed by nuclear translocation of NF-κB.

References

[1] Se Kyoo Jeong, et al. J Dermatol Sci. 2015, 79(3): 229-234.
[2] Shivtaj Mann, et al. J Immunol. 2018, 200 (1 Supplement) 170.14.