[CAS NO. 256925-03-8] AL082D06
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PRODUCTS SPECIFICATIONS [256925-03-8]
Distributor
Catalog
SLK-S6608
Brand
Selleck
CAS
256925-03-8
DESCRIPTION [256925-03-8]
Overview
| MDL | MFCD00100145 |
|---|---|
| Molecular Weight | 409.91 |
| Molecular Formula | C23H24ClN3O2 |
| SMILES | O=[N+](C1=CC=C(Cl)C(C(C2=CC=C(N(C)C)C=C2)C3=CC=C(N(C)C)C=C3)=C1)[O-] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4396 mL | 12.1978 mL | 24.3956 mL |
| 5 mM | 0.4879 mL | 2.4396 mL | 4.8791 mL |
| 10 mM | 0.2440 mL | 1.2198 mL | 2.4396 mL |
| 50 mM | - | - | - |
Description
AL082D06 is a nonsteroidal antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
Targets
| Glucocorticoid receptor [1] |
| 210 nM(Ki) |
In vitro
D06 can antagonize steroid-mediated induction of glutamine synthetase RNA in MG63 cells and TAT enzyme in human skin fibroblasts. It can act to inhibit both transcriptional activation and repression by receptor in a variety of cell types on a variety of genes. D06 partially blocks glucocorticoid receptor (GR) translocation to the nucleus, and completely blocks DNA binding by the receptor.
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