Overview MDL MFCD00140737 Molecular Weight 380.77 Molecular Formula C16H8ClF3N4S SMILES FC(C1=NN=C2N1C3=C(C=CC(Cl)=C3)N=C2SC4=CC=CC=C4)(F)F
For research use only.
Storage 3 years,-20°C,powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions Concentration Volume Mass 1 mg 5 mg 10 mg 1 mM 2.6263 mL 13.1313 mL 26.2626 mL 5 mM 0.5253 mL 2.6263 mL 5.2525 mL 10 mM 0.2626 mL 1.3131 mL 2.6263 mL 50 mM - - -
Description R-7050 is a cell permeable antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.
Targets TNF-α [2] IL-1β [2] 0.63 μM(EC50) 1.45 μM(EC50)
In vitro R-7050 has a clear selectivity toward TNFα and to a slightly weaker extent toward the LPA receptor which belongs to a GPCR class over IL-1β, tyrosine kinase, or Fas receptor systems.
