[CAS NO. 28643-80-3]  Nigericin (NSC 292567) sodium salt

In vitro model of tumor heterogeneity the antitumor effects of Nigericin (NIG) that works by acting as an H, K, and Pb ionophore. NIG decreased the viability and clonogenicity of H460 cells, as well as their ability to migrate and invade .Using a combination of live-cell imaging and biochemical approaches, we demonstrate that prototypical NLRP3 stimuli, the potassium ionophore nigericin, or millimolar concentrations of ATP exert both NLRP3-independent and -dependent effects on macrophages that result in cytokine release and cell death.