[CAS NO. 28643-80-3]  Nigericin (NSC 292567) sodium salt

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PRODUCTS SPECIFICATIONS [28643-80-3]

Catelog
SLK-S6653
Brand
Selleck
CAS
28643-80-3

DESCRIPTION [28643-80-3]

Overview

MDLMFCD27977549
Molecular Weight746.94
Molecular FormulaC40H67NaO11
SMILESC[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.3388 mL6.6940 mL13.3880 mL
5 mM0.2678 mL1.3388 mL2.6776 mL
10 mM0.1339 mL0.6694 mL1.3388 mL
50 mM0.0268 mL0.1339 mL0.2678 mL

Description

Nigericin (NSC 292567) sodium salt is an antibiotic derived from that works by acting as an .Nigericin can activate inflammasome to induce pro-inflammatory and immunostimulatory processes.

Targets

Potassium channel [1]Hydrogen channel [1]Pb 2+ [1]NLRP3 [2]

In vitro

In vitro model of tumor heterogeneity the antitumor effects of Nigericin (NIG) that works by acting as an H, K, and Pb ionophore. NIG decreased the viability and clonogenicity of H460 cells, as well as their ability to migrate and invade .Using a combination of live-cell imaging and biochemical approaches, we demonstrate that prototypical NLRP3 stimuli, the potassium ionophore nigericin, or millimolar concentrations of ATP exert both NLRP3-independent and -dependent effects on macrophages that result in cytokine release and cell death.


Synonyms

Nigericin, sodium salt (1:1)
Nigericin, monosodium salt
1,6-Dioxaspiro[4.5]decane, nigericin deriv.
Nigericin sodium salt
Sodium nigericin
NSC 292567