[CAS NO. 28643-80-3] Nigericin (NSC 292567) sodium salt

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PRODUCTS SPECIFICATIONS [28643-80-3]

Catalog

SLK-S6653

Brand

Selleck

CAS

28643-80-3

DESCRIPTION [28643-80-3]

Overview

MDL	MFCD27977549
Molecular Weight	746.94
Molecular Formula	C40H67NaO11
SMILES	C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.3388 mL	6.6940 mL	13.3880 mL
5 mM	0.2678 mL	1.3388 mL	2.6776 mL
10 mM	0.1339 mL	0.6694 mL	1.3388 mL
50 mM	0.0268 mL	0.1339 mL	0.2678 mL

Description

Nigericin (NSC 292567) sodium salt is an antibiotic derived from that works by acting as an .Nigericin can activate inflammasome to induce pro-inflammatory and immunostimulatory processes.

Targets

Potassium channel ^[1]

Hydrogen channel ^[1]

Pb 2+ ^[1]

NLRP3 ^[2]

In vitro

In vitro model of tumor heterogeneity the antitumor effects of Nigericin (NIG) that works by acting as an H, K, and Pb ionophore. NIG decreased the viability and clonogenicity of H460 cells, as well as their ability to migrate and invade .Using a combination of live-cell imaging and biochemical approaches, we demonstrate that prototypical NLRP3 stimuli, the potassium ionophore nigericin, or millimolar concentrations of ATP exert both NLRP3-independent and -dependent effects on macrophages that result in cytokine release and cell death.

References

[1] Juan Sebastian Yakisich,et al.Tumour Biol.2017;39 (3): 1010428317694310.
[2] Michelle E Heid,et al.J Immunol.2013;191 (10): 5230-5238.
[3] Huang D, et al. Biomed Pharmacother. 2022 Jun;150:112978.

Synonyms

Nigericin, sodium salt (1:1)

Nigericin, monosodium salt

1,6-Dioxaspiro[4.5]decane, nigericin deriv.

Nigericin sodium salt

Sodium nigericin

NSC 292567