Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.2176 mL
11.0879 mL
22.1759 mL
5 mM
0.4435 mL
2.2176 mL
4.4352 mL
10 mM
0.2218 mL
1.1088 mL
2.2176 mL
50 mM
0.0444 mL
0.2218 mL
0.4435 mL
Description
Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
The combination therapy of Seclidemstat (SP-2577) with checkpoint inhibitors may induce or augment immunogenic responses of SWI/SNF-mutated ovarian cancers. Seclidemstat promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) cell lines. Seclidemstat (3 μM) promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.
