[CAS NO. 950912-80-8] PF-670462

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [950912-80-8]

Catalog

SLK-S6734

Brand

Selleck

CAS

950912-80-8

DESCRIPTION [950912-80-8]

Overview

MDL	MFCD12828759
Molecular Weight	410.32
Molecular Formula	C19H22Cl2FN5
SMILES	NC=1N=C(C2=C(N=CN2C3CCCCC3)C4=CC=C(F)C=C4)C=CN1.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4371 mL	12.1856 mL	24.3712 mL
5 mM	0.4874 mL	2.4371 mL	4.8742 mL
10 mM	0.2437 mL	1.2186 mL	2.4371 mL
50 mM	0.0487 mL	0.2437 mL	0.4874 mL

Description

PF-670462 is a potent and selective inhibitor of and with IC50 value of 90 nM and 13 nM, respectively.

Targets

CK1δ ^[1] (Cell-free assay)	CK1ε ^[1] (Cell-free assay)
13 nM	90 nM

In vitro

PF-670462 is a 14 nM inhibitor of CK1δ in vitro and also potently inhibits p38 and EGFR. In vitro, PF670462 prevents TGF-β-induced epithelial-mesenchymal transition.

References

[1] Mathieu Bibian, et al. Bioorg Med Chem Lett. 2013, 23(15): 4374–4380.
[2] Keenan CR, et al. Front Pharmacol. 2018, 9:738.

Synonyms

2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, hydrochloride (1:2)

PF 670462