Overview
| MDL | MFCD28502206 |
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| Molecular Weight | 418.46 |
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| Molecular Formula | C22H25F3N4O |
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| SMILES | OC(C)([C@H]1CC[C@@H](CC1)NC2=NN3C(C=C2)=NC=C3C4=CC=CC(C(F)(F)F)=C4)C |
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For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg |
| 1 mM | 2.3897 mL | 11.9486 mL | 23.8971 mL |
| 5 mM | 0.4779 mL | 2.3897 mL | 4.7794 mL |
| 10 mM | 0.2390 mL | 1.1949 mL | 2.3897 mL |
| 50 mM | 0.0478 mL | 0.2390 mL | 0.4779 mL |
Description
TP-3654 is the second-generation inhibitor with K values of 5 nM, 239 nM, and 42 nM for PIM-1, PIM-2 and PIM-3, respectively.
Targets
Pim1 [1]
(Cell-free assay) | Pim3 [1]
(Cell-free assay) | Pim2 [1]
(Cell-free assay) |
| 5 nM(Ki) | 42 nM(Ki) | 239 nM(Ki) |
