[CAS NO. 139298-40-1] KN-93

Name: KN-93
Brand: Arctom Scientific
SKU: SLK-S6787

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PRODUCTS SPECIFICATIONS [139298-40-1]

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Catalog

SLK-S6787

Brand

Selleck

CAS

139298-40-1

DESCRIPTION [139298-40-1]

Overview

MDL	MFCD00236424
Molecular Weight	501.04
Molecular Formula	C26H29ClN2O4S
SMILES	N(S(=O)(=O)C1=CC=C(OC)C=C1)(CCO)C2=C(CN(CC=CC3=CC=C(Cl)C=C3)C)C=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9958 mL	9.9792 mL	19.9585 mL
5 mM	0.3992 mL	1.9958 mL	3.9917 mL
10 mM	0.1996 mL	0.9979 mL	1.9958 mL
50 mM	0.0399 mL	0.1996 mL	0.3992 mL

Description

KN-93 is a cell-permeable, reversible and competitive inhibitor of with Ki of 2.58 μM at rabbit myocardial CaM kinase activity.

Targets

CaMKII ^[1]
(Cell-free assay)

2.58 μM(Ki)

In vitro

KN-93, a CaMK2 inhibitor, reduces the B-cell differentiation and IgG production by differentiated plasma cells, and inhibits Blimp-1 expression in B cells.

References

[1] Anderson ME, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
[2] Li X, et al. Front Immunol. 2021;12:779560.
[3] Zhu Q, et al. Oxid Med Cell Longev. 2021;2021:4187398.

Synonyms

Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-

Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-

N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

KN 93