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[CAS NO. 1798331-92-6]
QX77
SDS
COA
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PRODUCTS SPECIFICATIONS [1798331-92-6]
Catalog
SLK-S6797
Brand
Selleck
CAS
1798331-92-6
DESCRIPTION [1798331-92-6]
Overview
MDL
-
Molecular Weight
300.74
Molecular Formula
C16H13ClN2O2
SMILES
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
Concentration
Volume
Mass
1 mg
5 mg
10 mg
1 mM
3.3251 mL
16.6257 mL
33.2513 mL
5 mM
0.6650 mL
3.3251 mL
6.6503 mL
10 mM
0.3325 mL
1.6626 mL
3.3251 mL
50 mM
0.0665 mL
0.3325 mL
0.6650 mL
Description
QX77 is a novel activator of . QX77 induces the up-regulation of Rab11 expression and up-regulates LAMP2A expression.
Targets
CMA
[1]
In vitro
QX77, an activator of CMA, eliminates the effects of milk fat globule-EGF factor 8 (MFG-E8) on TGF-β1-induced human pancreatic stellate cells (PSCs) activation. QX77 mitigates the suppressive effect of MFG-E8 on oxidative stress in activated PSCs.
References
[1] Zhang J, et al. J Biol Chem. 2017 Jun 23;292(25):10328-10346.
[2] Ren Y, et al. Front Pharmacol. 2021 Aug 5;12:707259.