Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.4083 mL
12.0415 mL
24.0830 mL
5 mM
0.4817 mL
2.4083 mL
4.8166 mL
10 mM
0.2408 mL
1.2042 mL
2.4083 mL
50 mM
0.0482 mL
0.2408 mL
0.4817 mL
Description
RU.521 (RU320521) is an active, potent and selective inhibitor of that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.
RU.521, a cGAS inhibitor, impares the overexpression of interferon-stimulated genes (ISGs) in response to cytolethal distending toxin (CDT), confirming the crucial role of cGAS-STING axis in CDT-induced type I IFN signaling.
