[CAS NO. 2262452-06-0] RU.521
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PRODUCTS SPECIFICATIONS [2262452-06-0]
Catalog
SLK-S6841
Brand
Selleck
CAS
2262452-06-0
DESCRIPTION [2262452-06-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 415.23 |
| Molecular Formula | C19H12Cl2N4O3 |
| SMILES | ClC1=C2C(N=C(N3C(O)=C(C4OC(C5=C4C=CC=C5)=O)C(C)=N3)N2)=CC=C1Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4083 mL | 12.0415 mL | 24.0830 mL |
| 5 mM | 0.4817 mL | 2.4083 mL | 4.8166 mL |
| 10 mM | 0.2408 mL | 1.2042 mL | 2.4083 mL |
| 50 mM | 0.0482 mL | 0.2408 mL | 0.4817 mL |
Description
RU.521 (RU320521) is an active, potent and selective inhibitor of that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.
In vitro
RU.521, a cGAS inhibitor, impares the overexpression of interferon-stimulated genes (ISGs) in response to cytolethal distending toxin (CDT), confirming the crucial role of cGAS-STING axis in CDT-induced type I IFN signaling.
References
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