[CAS NO. 187389-52-2] Z-VAD-FMK

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Catalog:	SLK-S7023
Brand:	Selleck
CAS:	187389-52-2

Overview

MDL	MFCD02684037
Molecular Weight	467.49
Molecular Formula	C22H30FN3O7
SMILES	[C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)C)=O)(CC(OC)=O)C(CF)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1391 mL	10.6954 mL	21.3908 mL
5 mM	0.4278 mL	2.1391 mL	4.2782 mL
10 mM	0.2139 mL	1.0695 mL	2.1391 mL
50 mM	0.0428 mL	0.2139 mL	0.4278 mL

Description

Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan- inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

Features

A key compound for apoptosis studies.

Targets

Pan-caspase ^[1]
(THP.1, Jurkat T-cells)

In vitro

Z-VAD-FMK (10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay.

References

[1] Slee EA, et al. Biochem J, 1996, 315 (Pt 1), 21-24.
[2] Shimizu T, et al. Leukemia, 1997, 11(8), 1238-1244.
[3] Ilangovan R, et al. J Biol Chem, 2003, 278(33), 30993-30999.
[4] Cowburn AS, et al. Blood, 2005, 105(7), 2970-2972.
[5] Kim WJ, et al. Exp Eye Res, 2000, 71(3), 225-232.
[6] Fransolet M, et al. J Assist Reprod Genet. 2015, 32(10):1551-9.
[7] Equils O, et al. Infect Dis Obstet Gynecol. 2009, 2009:749432.

Synonyms

L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-

N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide

3: PN: WO0158526 SEQID: 3 claimed sequence

Z-VAD(OMe)-FMK

13: PN: WO2005039629 PAGE: 18 claimed protein

3: PN: WO2011028611 SEQID: 3 unclaimed protein

Z-Val-Ala-Asp(OMe)-FMK

z-VAD-fmk

z-VAD-FMK

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