[CAS NO. 1059734-66-5]  BMS-833923

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PRODUCTS SPECIFICATIONS [1059734-66-5]

Catalog
SLK-S7138
Brand
Selleck
CAS
1059734-66-5

DESCRIPTION [1059734-66-5]

Overview

MDLMFCD25976660
Molecular Weight473.57
Molecular FormulaC30H27N5O
SMILESO=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.1116 mL10.5581 mL21.1162 mL
5 mM0.4223 mL2.1116 mL4.2232 mL
10 mM0.2112 mL1.0558 mL2.1116 mL
50 mM0.0422 mL0.2112 mL0.4223 mL

Description

BMS-833923 (XL139) is an orally bioavailable antagonist. Phase 2.

Targets

Smoothened [1]

In vitro

BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the intrinsic pathway in esophageal adenocarcinoma (EAC) cell lines. BMS-833923 dose-dependently affects canonical and prostate hedgehog signature gene transcription in vitro.