[CAS NO. 154039-60-8] Marimastat (BB-2516)

Name: Marimastat (BB-2516)
Brand: Arctom Scientific
SKU: SLK-S7156

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PRODUCTS SPECIFICATIONS [154039-60-8]

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Catalog

SLK-S7156

Brand

Selleck

CAS

154039-60-8

DESCRIPTION [154039-60-8]

Overview

MDL	MFCD00866242
Molecular Weight	331.41
Molecular Formula	C15H29N3O5
SMILES	[C@H](C(N[C@H](C(NC)=O)[C@](C)(C)C)=O)([C@@H](C(NO)=O)O)CC(C)C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0174 mL	15.0871 mL	30.1741 mL
5 mM	0.6035 mL	3.0174 mL	6.0348 mL
10 mM	0.3017 mL	1.5087 mL	3.0174 mL
50 mM	0.0603 mL	0.3017 mL	0.6035 mL

Description

Marimastat (BB-2516, TA2516) is a broad spectrum inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.

Targets

In vitro

Marimastat (100 nM) signiﬁcantly inhibits the expression of MMP14 in U251, U87, GBM39, and GBM43 tumor cells. Marimastat speciﬁcally inhibits the growth of glioma cells and has no effect on normal human astrocytes (NHA).Marimastat early down-regulates the expression of Notch target genes, such as Hes1 and Hes5.

References

[1] Rasmussen HS, et al. Pharmacol Ther. 1997, 75(1), 69-75.
[2] auf dem Keller U, et al. Cancer Res. 2010, 70(19), 7562-7569.
[3] Ulasov I, et al. Cancer Med.?013, 2(4), 457-467.
[4] Sinno M, et al. Stem Cells Dev. 2013, 22(3), 345-358.
[5] Maekawa K, et al. Clin Exp Metastasis. 2002, 19(6), 513-518.
[6] Urribarri AD, et al. Gut. 2014, 63(10), 1658-1667.

Synonyms

Butanediamide, N⁴-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N¹,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-

Butanediamide, N⁴-[2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N¹,2-dihydroxy-3-(2-methylpropyl)-, [2S-[N⁴(R*),2R*,3S*]]-

(2S,3R)-N⁴-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N¹,2-dihydroxy-3-(2-methylpropyl)butanediamide

BB 2516

Marimastat

GI 5712

TA 2516

KB-R 8898