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Catalog:
SLK-S7237
Brand:
Selleck
CAS:
1357302-64-7
Overview
MDL
MFCD27997969
Molecular Weight
225.29
Molecular Formula
C15H15NO
SMILES
OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
4.4387 mL
22.1936 mL
44.3872 mL
5 mM
0.8877 mL
4.4387 mL
8.8774 mL
10 mM
0.4439 mL
2.2194 mL
4.4387 mL
50 mM
0.0888 mL
0.4439 mL
0.8877 mL
Description
OG-L002 is a potent and specific inhibitor with of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
Features
This selective LSD1 inhibitor was discovered in 2013. Potential for use in viral diseases such as HSV and VZV.
OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene.
In vivo
OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.
