[CAS NO. 1419949-20-4] NVP-TNKS656
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PRODUCTS SPECIFICATIONS [1419949-20-4]
Store
Catalog
SLK-S7238
Brand
Selleck
CAS
1419949-20-4
DESCRIPTION [1419949-20-4]
Overview
| MDL | MFCD28167762 |
|---|---|
| Molecular Weight | 494.58 |
| Molecular Formula | C27H34N4O5 |
| SMILES | O=C(N(CC1CC1)CC2=NC3=C(COCC3)C(N2)=O)CN4CCC(C(C5=CC=C(OC)C=C5)=O)CC4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
NVP-TNKS656 is a highly potent, selective, and orally active inhibitor with of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.
Targets
| TNKS2 [1] (Cell-free assay) |
| 6 nM |
In vitro
In vitro, NVP-TNKS656 shows low to moderate microsomal ER values across species and high solubility. In PI3K or AKT inhibitor-resistant cells, NVP-TNKS656 blocks Wnt/β-Catenin pathway and promotes apoptosis.
References
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