[CAS NO. 1417329-24-8] MM-102
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PRODUCTS SPECIFICATIONS [1417329-24-8]
Catalog
SLK-S7265
Brand
Selleck
CAS
1417329-24-8
DESCRIPTION [1417329-24-8]
Overview
| MDL | MFCD28015099 |
|---|---|
| Molecular Weight | 669.8 |
| Molecular Formula | C35H49F2N7O4 |
| SMILES | O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4930 mL | 7.4649 mL | 14.9298 mL |
| 5 mM | 0.2986 mL | 1.4930 mL | 2.9860 mL |
| 10 mM | 0.1493 mL | 0.7465 mL | 1.4930 mL |
| 50 mM | 0.0299 mL | 0.1493 mL | 0.2986 mL |
Description
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the protein-protein interaction, which bind to WDR5 with Ki < 1 nM and =2.4nM.
Targets
| MLL1 [1] (Cell-free assay) |
| 0.4 μM |
In vitro
MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and K of < 1 nM. In the MLL1-AF9 transduced murine cells, MM-102 specifically reduces expression of two critical MLL1 target genes (HoxA9 and Meis-1), which are required for MLL1 mediated leukemogenesis. In addition, MM-102 effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.
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