Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.4930 mL
7.4649 mL
14.9298 mL
5 mM
0.2986 mL
1.4930 mL
2.9860 mL
10 mM
0.1493 mL
0.7465 mL
1.4930 mL
50 mM
0.0299 mL
0.1493 mL
0.2986 mL
Description
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the protein-protein interaction, which bind to WDR5 with Ki < 1 nM and =2.4nM.
MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and K of < 1 nM. In the MLL1-AF9 transduced murine cells, MM-102 specifically reduces expression of two critical MLL1 target genes (HoxA9 and Meis-1), which are required for MLL1 mediated leukemogenesis. In addition, MM-102 effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.
