[CAS NO. 1139889-93-2] Golgicide A
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PRODUCTS SPECIFICATIONS [1139889-93-2]
Store
Catalog
SLK-S7266
Brand
Selleck
CAS
1139889-93-2
DESCRIPTION [1139889-93-2]
Overview
| MDL | MFCD27937048 |
|---|---|
| Molecular Weight | 284.3 |
| Molecular Formula | C17H14F2N2 |
| SMILES | FC1=CC2=C(NC(C3=CC=CN=C3)[C@@]4([H])[C@]2([H])C=CC4)C(F)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5174 mL | 17.5871 mL | 35.1741 mL |
| 5 mM | 0.7035 mL | 3.5174 mL | 7.0348 mL |
| 10 mM | 0.3517 mL | 1.7587 mL | 3.5174 mL |
| 50 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL |
Description
Golgicide A is a potent and rapidly reversible inhibitor.
Targets
| GBF1 [1] |
In vitro
Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells.
References
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