[CAS NO. 260415-63-2] PD173955

Name: PD173955
Brand: Arctom Scientific
SKU: SLK-S7269

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PRODUCTS SPECIFICATIONS [260415-63-2]

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Catalog

SLK-S7269

Brand

Selleck

CAS

260415-63-2

DESCRIPTION [260415-63-2]

Overview

MDL	-
Molecular Weight	443.35
Molecular Formula	C21H16Cl2N4OS
SMILES	O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2556 mL	11.2778 mL	22.5555 mL
5 mM	0.4511 mL	2.2556 mL	4.5111 mL
10 mM	0.2256 mL	1.1278 mL	2.2556 mL
50 mM	-	-	-

Description

PD173955 is a potent inhibitor with of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.

Targets

Bcr-Abl ^[1]	Src ^[2]
1 nM-2 nM	22 nM

In vitro

PD173955 potently inhibits Bcr-Abl-dependent cell growth with IC50 of 2-35 nM in Bcr-Abl-positive cell lines, about 100- to 200-fold more sensitive than in Bcr-Abl-negative cell lines. PD173955 also inhibits kit ligand-dependent proliferation of M07e cells with IC50 of 40 nM, by inhibition of kit ligand-dependent c-kit autophosphorylation. In addition, PD173955, as a Src inhibitor, potently inhibits mitotic progression during early mitosis in cells of all types and induces varying degrees of apoptotic cell death.

References

[1] Wisniewski D, et al. Cancer Res. 2002, 62(15), 4244-4255.
[2] Moasser MM, et al. Cancer Res. 1999, 59(24), 6145-6152.