Please click "REQUEST A QUOTE" button if there is no stock, or
you need other sizes or custom synthesis.
Catalog:
SLK-S7281
Brand:
Selleck
CAS:
199596-05-9
Overview
MDL
MFCD26936344
Molecular Weight
308.76
Molecular Formula
C17H13ClN4
SMILES
ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.2388 mL
16.1938 mL
32.3876 mL
5 mM
0.6478 mL
3.2388 mL
6.4775 mL
10 mM
0.3239 mL
1.6194 mL
3.2388 mL
50 mM
0.0648 mL
0.3239 mL
0.6478 mL
Description
JIB-04 (NSC 693627) is a pan-selective inhibitor with of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell .
Targets
In vitro
JIB-04 induces transcriptional changes in a cancer-selective manner, including the downregulation of proliferative genes and the upregulation of the anti-proliferative/pro-apoptotic genes. JIB-04 blocks growth of lung and prostate cancer lines with IC50 as low as 10 nM, while produces less anti-proliferative activities on HBECs and PrSCs/PrECs.
In vivo
In two separate xenograft mouse models (H358 or A549), JIB-04 diminishes tumor growth, lowers Jumonji histone demethylase activity in tumors, and prolongs cancer survival.
