Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.9206 mL
9.6030 mL
19.2060 mL
5 mM
0.3841 mL
1.9206 mL
3.8412 mL
10 mM
0.1921 mL
0.9603 mL
1.9206 mL
50 mM
0.0384 mL
0.1921 mL
0.3841 mL
Description
NMS-873 is an allosteric and specific inhibitor with of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
Features
The most potent and specific p97 inhibitor described to date.
NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death.
