[CAS NO. 4382-63-2] PFK15
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PRODUCTS SPECIFICATIONS [4382-63-2]
Catalog
SLK-S7289
Brand
Selleck
CAS
4382-63-2
DESCRIPTION [4382-63-2]
Overview
| MDL | MFCD28099813 |
|---|---|
| Molecular Weight | 260.29 |
| Molecular Formula | C17 H12 N2 O |
| SMILES | O=C(C1=CC=NC=C1)C=CC2=NC3=CC=CC=C3C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
PFK15 (PFK-015) is a potent and selective inhibitor with of 207 nM.
Targets
| PFKFB3 [1] (Cell-free assay) |
| 207 nM |
In vitro
PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.
In vivo
In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
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