Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
1.8657 mL
9.3287 mL
18.6574 mL
5 mM
0.3731 mL
1.8657 mL
3.7315 mL
10 mM
0.1866 mL
0.9329 mL
1.8657 mL
50 mM
0.0373 mL
0.1866 mL
0.3731 mL
Description
PFI-2 is a potent, selective, and cell-active inhibitor with and of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
(R)-PFI-2 shows 500-fold more inhibitory activity against human SETD7 than its enantiomer, (S)-PFI-2. In a cellular environment, through direct interactions with SETD7, affects Yes-Associated protein localization and phenocopies Setd7 genetic deletion on Hippo pathway signaling.
