[CAS NO. 1395084-25-9] MS436
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PRODUCTS SPECIFICATIONS [1395084-25-9]
Distributor
Catalog
SLK-S7305
Brand
Selleck
CAS
1395084-25-9
DESCRIPTION [1395084-25-9]
Overview
| MDL | MFCD27992062 |
|---|---|
| Molecular Weight | 383.42 |
| Molecular Formula | C18H17N5O3S |
| SMILES | O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3=NC=CC=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6081 mL | 13.0405 mL | 26.0811 mL |
| 5 mM | 0.5216 mL | 2.6081 mL | 5.2162 mL |
| 10 mM | 0.2608 mL | 1.3041 mL | 2.6081 mL |
| 50 mM | 0.0522 mL | 0.2608 mL | 0.5216 mL |
Description
MS436 is a selective inhibitor with of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively.
In vitro
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability.
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