[CAS NO. 1613724-42-7] HTH-01-015
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PRODUCTS SPECIFICATIONS [1613724-42-7]
Store
Catalog
SLK-S7318
Brand
Selleck
CAS
1613724-42-7
DESCRIPTION [1613724-42-7]
Overview
| MDL | MFCD28167816 |
|---|---|
| Molecular Weight | 468.55 |
| Molecular Formula | C26H28N8O |
| SMILES | O=C1C2=CC3=CC=CC=C3C=C2N(C)C4=NC(NC5=CN(C6CCNCC6)N=C5)=NC(C)=C4N1C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1342 mL | 10.6712 mL | 21.3424 mL |
| 5 mM | 0.4268 mL | 2.1342 mL | 4.2685 mL |
| 10 mM | 0.2134 mL | 1.0671 mL | 2.1342 mL |
| 50 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL |
Description
HTH-01-015 is a potent and selective inhibitor with of 100 nM, >100-fold selectivity over NUAK2.
Targets
| NUAK1 [1] |
| 100 nM |
In vitro
In HEK-293 cells express NUAK1 as well as NUAK2, HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation. HTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. HTH-01-015 inhibitors markedly restricted cells from entering into mitosis in U2OS cells.
References
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