Overview
| MDL | MFCD28142814 |
|---|
| Molecular Weight | 463.58 |
|---|
| Molecular Formula | C25H33N7O2 |
|---|
| SMILES | O=C(C1=CN=C(NCCCC)N=C1N[C@H]2CC[C@H](O)CC2)NCC3=CC=C(N4C=CN=C4)C=C3 |
|---|
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg |
| 1 mM | 2.1571 mL | 10.7856 mL | 21.5712 mL |
| 5 mM | 0.4314 mL | 2.1571 mL | 4.3142 mL |
| 10 mM | 0.2157 mL | 1.0786 mL | 2.1571 mL |
| 50 mM | 0.0431 mL | 0.2157 mL | 0.4314 mL |
Description
UNC2881 is a specific inhibitor with of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.
Targets
Mer [1]
(Cell-free assay) | Tyro3 [1]
(Cell-free assay) | Axl [1]
(Cell-free assay) |
| 4.3 nM | 250 nM | 360 nM |
In vitro
UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation.
In vivo
UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice.
