[CAS NO. 66701-25-5] E-64

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Catalog:	SLK-S7379
Brand:	Selleck
CAS:	66701-25-5

Overview

MDL	MFCD00080261
Molecular Weight	357.41
Molecular Formula	C15H27N5O5
SMILES	C(N[C@H](C(NCCCCNC(=N)N)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7979 mL	13.9895 mL	27.9791 mL
5 mM	0.5596 mL	2.7979 mL	5.5958 mL
10 mM	0.2798 mL	1.3990 mL	2.7979 mL
50 mM	0.0560 mL	0.2798 mL	0.5596 mL

Description

E-64 is an irreversible and selective inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and in Filarial Parasite.

Targets

Cysteine protease ^[1]
(Cell-free assay)

9 nM

In vitro

E-64 rapidly inhibits the activities of the cysteine proteinases cathepsins B, H and L and papain, while has no effect on the serine proteinases or the metalloproteinases. E-64, as a specific inhibitor os cysteine proteases, effectively blocks in vitro ovarian cancer cell invasion. In addition, E-64 also shows antiparasitic activity against Giardia lamblia excystation in vitro. E-64 improves the preimplantation development of bovine somatic cell nuclear transfer embryos, which indicates another important implication of E-64.

References

[1] Matsumoto K, et al. Biopolymers. 1999, 51(1), 99-107.
[2] Barrett AJ, et al. Biochem J. 1982, 201(1), 189-198.
[3] Kobayashi H, et al. Cancer Res. 1992, 52(13), 3610-3614.
[4] Hussein EM, et al. J Egypt Soc Parasitol. 2009, 39(1), 111-119.
[5] Min SH, et al. J Reprod Dev. 2014, 60(1), 21-27.
[6] Leto G, et al. In Vivo. 1994 , 8(2), 231-236.

Synonyms

2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-

Oxiranecarboxylic acid, 3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-

Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-

(2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid

Proteinase inhibitor E 64

E 64 (proteinase inhibitor)

E 64

trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane

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