[CAS NO. 76684-89-4] Loxistatin Acid (E-64C)

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PRODUCTS SPECIFICATIONS [76684-89-4]

Catalog

SLK-S7392

Brand

Selleck

CAS

76684-89-4

DESCRIPTION [76684-89-4]

Overview

MDL	MFCD00132882
Molecular Weight	314.38
Molecular Formula	C15H26 N2 O5
SMILES	C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1809 mL	15.9043 mL	31.8086 mL
5 mM	0.6362 mL	3.1809 mL	6.3617 mL
10 mM	0.3181 mL	1.5904 mL	3.1809 mL
50 mM	0.0636 mL	0.3181 mL	0.6362 mL

Description

Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant inhibitor. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry.

Targets

cysteine protease ^[1]

In vitro

Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease.

In vivo

In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.

References

[1] McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435.
[2] Noda T, et al. J Biochem. 1981, 90(3), 893-896.
[3] Inuzuka T, et al. Brain Res. 1990, 526(1), 177-179.
[4] Hook VY, et al. J Neurosci Res. 2003, 74(3), 393-405.

Synonyms

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, (2S,3S)-

Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-

Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, (2S,3S)-

(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid

Ep 475

E 64c

Ep 475 (enzyme inhibitor)

Loxistatin acid

NSC 694279