[CAS NO. 313967-18-9] FLI-06
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PRODUCTS SPECIFICATIONS [313967-18-9]
Store
Catalog
SLK-S7399
Brand
Selleck
CAS
313967-18-9
DESCRIPTION [313967-18-9]
Overview
| MDL | MFCD00330996 |
|---|---|
| Molecular Weight | 438.52 |
| Molecular Formula | C25H30N2O5 |
| SMILES | O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C([N+]([O-])=O)C=C3)OC4CCCCC4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2804 mL | 11.4020 mL | 22.8040 mL |
| 5 mM | 0.4561 mL | 2.2804 mL | 4.5608 mL |
| 10 mM | 0.2280 mL | 1.1402 mL | 2.2804 mL |
| 50 mM | 0.0456 mL | 0.2280 mL | 0.4561 mL |
Description
FLI-06 is a novel inhibitor of signaling with of 2.3 μM.
Targets
| Notch [1] (Cell-based assay) |
| 2.3 μM(EC50) |
In vitro
In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.
In vivo
FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos.
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