[CAS NO. 3513-03-9] Blasticidin S HCl

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Catalog:	SLK-S7419
Brand:	Selleck
CAS:	3513-03-9

Overview

MDL	MFCD02091640
Molecular Weight	458.9
Molecular Formula	C17H27ClN8O5
SMILES	O=C1N([C@@H]2O[C@H](C(O)=O)[C@@H](NC(C[C@H](CCN(C(=N)N)C)N)=O)C=C2)C=CC(N)=N1.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1791 mL	10.8956 mL	21.7912 mL
5 mM	0.4358 mL	2.1791 mL	4.3582 mL
10 mM	0.2179 mL	1.0896 mL	2.1791 mL
50 mM	0.0436 mL	0.2179 mL	0.4358 mL

Description

Blasticidin S HCl is a nucleoside isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

Targets

protein synthesis ^[1]

DNA synthesis ^[1]

In vitro

Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA. Blasticidin S also significantly inhibits DNA synthesis independent of their effect on protein synthesis. Blasticidin S kills the cells more rapidly than G418, which makes blasticidin S-resistance gene (bsr) a selectable marker for mammalian cells. Besides, Blasticidin S also efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

References

[1] Yamaguchi H, et al. J Biochem. 1966, 60(6), 632-642.
[2] Sullia SB, et al. Biochim Biophys Acta. 1977, 5(1), 14-22.
[3] Izumi M, et al. Exp Cell Res. 1991, 197(2), 229-233.
[4] Stokowa-Sołtys K, et al. J Inorg Biochem. 2013, 127, 73-78.
[5] Wang P, et al. Nat Chem Biol. 2019 Nov;15(11):1110-1119.
[6] Gullo V, et al. J Antibiot (Tokyo). 1988 Jan;41(1):20-4.

Synonyms

β-D-erythro-Hex-2-enopyranuronic acid, 4-[[(3S)-3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, hydrochloride (1:1)

Blasticidin S, monohydrochloride

β-D-erythro-Hex-2-enopyranuronic acid, 4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, monohydrochloride, (S)-

β-D-erythro-Hex-2-enopyranuronic acid, 4-[[(3S)-3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, monohydrochloride

Blasticidin S hydrochloride

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