[CAS NO. 1445251-22-8] ME0328
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PRODUCTS SPECIFICATIONS [1445251-22-8]
Store
Catalog
SLK-S7438
Brand
Selleck
CAS
1445251-22-8
DESCRIPTION [1445251-22-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 321.37 |
| Molecular Formula | C19H19N3O2 |
| SMILES | O=C(N[C@H](C1=CC=CC=C1)C)CCC(N2)=NC3=C(C=CC=C3)C2=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1117 mL | 15.5584 mL | 31.1168 mL |
| 5 mM | 0.6223 mL | 3.1117 mL | 6.2234 mL |
| 10 mM | 0.3112 mL | 1.5558 mL | 3.1117 mL |
| 50 mM | 0.0622 mL | 0.3112 mL | 0.6223 mL |
Description
ME0328 is a potent and selective inhibitor with of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
In vitro
ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes. ME0328 (10 μM) results in a significant delay of γH2AX-foci resolution by affecting ARTD3 in A549 and MRC5 cells without significant toxicity.
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