[CAS NO. 747413-08-7] VER-50589
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PRODUCTS SPECIFICATIONS [747413-08-7]
Catalog
SLK-S7459
Brand
Selleck
CAS
747413-08-7
DESCRIPTION [747413-08-7]
Overview
| MDL | MFCD18382095 |
|---|---|
| Molecular Weight | 388.80 |
| Molecular Formula | C19H17ClN2O5 |
| SMILES | O=C(C1=NOC(C2=CC(Cl)=C(O)C=C2O)=C1C3=CC=C(OC)C=C3)NCC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5720 mL | 12.8601 mL | 25.7202 mL |
| 5 mM | 0.5144 mL | 2.5720 mL | 5.1440 mL |
| 10 mM | 0.2572 mL | 1.2860 mL | 2.5720 mL |
| 50 mM | 0.0514 mL | 0.2572 mL | 0.5144 mL |
Description
VER-50589 is a potent inhibitor with of 21 nM for HSP90β.
Targets
| HSP90β [1] |
| 21 nM |
In vitro
VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 143 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-50589 causes induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5, which further result in cell cycle arrest and apoptosis.
In vivo
In HCT116 human colon cancer xenografts, VER-50589 (100 mg/kg i.p.) results in a statistically significant reduction of ∼30% in tumor volume and weight, as well as induction of HSP72 and depletion of ERBB2 and C-RAF.
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