[CAS NO. 89464-63-1] DMOG
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PRODUCTS SPECIFICATIONS [89464-63-1]
Catalog
SLK-S7483
Brand
Selleck
CAS
89464-63-1
DESCRIPTION [89464-63-1]
Overview
| MDL | MFCD05865098 |
|---|---|
| Molecular Weight | 175.14 |
| Molecular Formula | C6H9NO5 |
| SMILES | O=C(OC)CNC(C(OC)=O)=O |
For research use only.
Storage
2 years -20°C liquid
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for , leading to stabilisation and accumulation of protein in the nucleus. DMOG enhances .
Targets
| HIF prolyl hydroxylase [1] |
In vitro
DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.
References
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