[CAS NO. 144217-65-2] YYA-021
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PRODUCTS SPECIFICATIONS [144217-65-2]
Store
Catalog
SLK-S7487
Brand
Selleck
CAS
144217-65-2
DESCRIPTION [144217-65-2]
Overview
| MDL | MFCD00738763 |
|---|---|
| Molecular Weight | 317.43 |
| Molecular Formula | C18 H27 N3 O2 |
| SMILES | O=C(NC1CC(C)(C)NC(C)(C)C1)C(NC2=CC=C(C)C=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1503 mL | 15.7515 mL | 31.5030 mL |
| 5 mM | 0.6301 mL | 3.1503 mL | 6.3006 mL |
| 10 mM | 0.3150 mL | 1.5752 mL | 3.1503 mL |
| 50 mM | - | - | - |
Description
YYA-021 is a CD4-mimic entry inhibitor, competitively inhibiting the interaction between and CD4.
Targets
| gp120 [1] |
In vitro
YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA.
In vivo
In rats and rhesus macaques, YYA-021 (i.v.) shows moderate half-lives, wide tissue distribution and relatively high distribution volumes.
References
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