Please click "REQUEST A QUOTE" button if there is no stock, or
you need other sizes or custom synthesis.
Catalog:
SLK-S7497
Brand:
Selleck
CAS:
442632-72-6
Overview
MDL
MFCD03036245
Molecular Weight
284.38
Molecular Formula
C16H16N2OS
SMILES
O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.5164 mL
17.5821 mL
35.1642 mL
5 mM
0.7033 mL
3.5164 mL
7.0328 mL
10 mM
0.3516 mL
1.7582 mL
3.5164 mL
50 mM
0.0703 mL
0.3516 mL
0.7033 mL
Description
CK-636 (CK-0944636) is an complex inhibitor with of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
