[CAS NO. 1033769-28-6] GNF-5837
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PRODUCTS SPECIFICATIONS [1033769-28-6]
Distributor
Catalog
SLK-S7519
Brand
Selleck
CAS
1033769-28-6
DESCRIPTION [1033769-28-6]
Overview
| MDL | MFCD24386809 |
|---|---|
| Molecular Weight | 535.49 |
| Molecular Formula | C28H21F4N5O2 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
GNF-5837 is a selective, and orally bioavailable pan- inhibitor for TrkA, and TrkB with of 8 nM, and 12 nM, respectively.
Targets
In vitro
In Ba/F3 cells overexpressing the constitutively active Tel-TRKC fusion, GNF-5837 shows potent anti-Trk activity and potent antiproliferation activity with IC50 of 0.042 μM.
In vivo
In both male Balb/c mice and Sprague–Dawley rats, GNF-5837 has the low drug clearance, and moderate biovailability. In mice bearing Rie xenografts expressing TrkA and NGF, GNF-5837 (100 mg/kg/d p.o.) significantly inhibits tumor growth.
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