[CAS NO. 1351761-44-8] GNE-7915
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PRODUCTS SPECIFICATIONS [1351761-44-8]
Catalog
SLK-S7528
Brand
Selleck
CAS
1351761-44-8
DESCRIPTION [1351761-44-8]
Overview
| MDL | MFCD25977005 |
|---|---|
| Molecular Weight | 443.40 |
| Molecular Formula | C19H21F4N5O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2553 mL | 11.2765 mL | 22.5530 mL |
| 5 mM | 0.4511 mL | 2.2553 mL | 4.5106 mL |
| 10 mM | 0.2255 mL | 1.1276 mL | 2.2553 mL |
| 50 mM | - | - | - |
Description
GNE-7915 is a highly potent, selective, and brain-penetrable inhibitor, with and of 9 nM and 1 nM, respectively.
In vitro
GNE-7915 is also a moderately potent 5-HT2B antagonist according to in vitro functional assays. GNE-7915 demonstrates excellent in vitro DMPK with minimal turnover in human hepatocytes.
In vivo
In rats, GNE-7915 demonstrates excellent in vivo PK profiles with long half-lives, good oral exposure and high passive permeability. GNE-7915 (50 mg/kg i.p. or p.o.) results in concentration-dependent knockdown of pLRRK2 in the brain of BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation.
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