Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.4845 mL
12.4227 mL
24.8453 mL
5 mM
0.4969 mL
2.4845 mL
4.9691 mL
10 mM
0.2485 mL
1.2423 mL
2.4845 mL
50 mM
0.0497 mL
0.2485 mL
0.4969 mL
Description
Pritelivir (BAY 57-1293, AIC316) is a potent inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with of 20 nM for both HSV-1 and HSV-2.
The mechanism of action is that BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 also shows potent antiviral activity against acyclovir resistant HSV mutants. BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells.
In vivo
BAY 57-1293 (p.o.) shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes (0.5 mg/kg), in a murine zosteriform spread model of cutaneous disease (15 mg/kg), and in a murine ocular herpes model.
