[CAS NO. 348086-71-5] Pritelivir (BAY 57-1293)

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PRODUCTS SPECIFICATIONS [348086-71-5]

Catelog

SLK-S7546

Brand

Selleck

CAS

348086-71-5

DESCRIPTION [348086-71-5]

Overview

MDL	-
Molecular Weight	402.49
Molecular Formula	C18 H18 N4 O3 S2
SMILES	N(C(CC1=CC=C(C=C1)C2=CC=CC=N2)=O)(C)C=3SC(S(N)(=O)=O)=C(C)N3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4845 mL	12.4227 mL	24.8453 mL
5 mM	0.4969 mL	2.4845 mL	4.9691 mL
10 mM	0.2485 mL	1.2423 mL	2.4845 mL
50 mM	0.0497 mL	0.2485 mL	0.4969 mL

Description

Pritelivir (BAY 57-1293, AIC316) is a potent inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with of 20 nM for both HSV-1 and HSV-2.

Targets

helicase primase ^[1]

In vitro

The mechanism of action is that BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 also shows potent antiviral activity against acyclovir resistant HSV mutants. BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells.

In vivo

BAY 57-1293 (p.o.) shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes (0.5 mg/kg), in a murine zosteriform spread model of cutaneous disease (15 mg/kg), and in a murine ocular herpes model.

References

[1] Kleymann G, et al. Nat Med. 2002, 8(4), 392-398.
[2] Betz UA, et al. Antimicrob Agents Chemother. 2002, 46(6), 1766-1772.
[3] Wozniak MA, et al. Antiviral Res. 2013, 99(3), 401-404.

Synonyms

Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-

N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide

BAY 57-1293

N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

Pritelivir