Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.5677 mL
12.8386 mL
25.6772 mL
5 mM
0.5135 mL
2.5677 mL
5.1354 mL
10 mM
0.2568 mL
1.2839 mL
2.5677 mL
50 mM
0.0514 mL
0.2568 mL
0.5135 mL
Description
GSK-J1 is a highly potent inhibitor of H3K27 JMJD3 (KDM6B) and UTX (KDM6A) with of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with of 0.95μM and 1.76μM towards JARID1B/C.
In HEK-293 cells, GSK-J1 inhibits the activities of transiently transfected JMJD3 and UTX. GSK-J1 also inhibits TNF-α production by human primary macrophages by increasing total nuclear H3K27me3 levels. In MC3T3-E1 cells, GSK-J1 suppresses Runx2 and Osterix expressions and ALP activity, and increases the global levels of H3K27me3.
