[CAS NO. 1374601-40-7] BRD4770
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PRODUCTS SPECIFICATIONS [1374601-40-7]
Catalog
SLK-S7591
Brand
Selleck
CAS
1374601-40-7
DESCRIPTION [1374601-40-7]
Overview
| MDL | MFCD23143627 |
|---|---|
| Molecular Weight | 413.47 |
| Molecular Formula | C25H23N3O3 |
| SMILES | O=C(C1=CC=C2N(CCCC3=CC=CC=C3)C(NC(C4=CC=CC=C4)=O)=NC2=C1)OC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
BRD4770 is a inhibitor with of 6.3 μM, and induces cell senescence.
Targets
| G9a [1] |
In vitro
BRD4770 reduces cellular levels of di- and trimethylated H3K9 via inhibition of G9a, induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. The combination of gossypol and BRD4770 increases LC3-II levels and the autophagosome number, and thus acts in synergy to induce cell death in PANC-1 cells.
References
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