[CAS NO. 627536-09-8] SD-208
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PRODUCTS SPECIFICATIONS [627536-09-8]
Catalog
SLK-S7624
Brand
Selleck
CAS
627536-09-8
DESCRIPTION [627536-09-8]
Overview
| MDL | MFCD11519969 |
|---|---|
| Molecular Weight | 352.75 |
| Molecular Formula | C17H10ClFN6 |
| SMILES | FC1=CC=C(Cl)C=C1C2=NC(NC3=CC=NC=C3)=C4N=CC=NC4=N2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8349 mL | 14.1743 mL | 28.3487 mL |
| 5 mM | 0.5670 mL | 2.8349 mL | 5.6697 mL |
| 10 mM | 0.2835 mL | 1.4174 mL | 2.8349 mL |
| 50 mM | - | - | - |
Description
SD-208 is a selective inhibitor with of 48 nM, >100-fold selectivity over TGF-βRII.
Targets
| TGF-βRI (ALK5) [1] (Cell-free assay) |
| 48 nM |
In vitro
SD-208 inhibits the cell growth and constitutive and TGF-beta-evoked migration and invasion, and enhances immunogenicity in murine SMA-560 and human LN-308 glioma cells. SD-208 blocka TGF-beta-induced phosphorylation of the receptor-associated Smads, Smad2 and Smad3, and stimulates epithelial-to-mesenchymal transdifferentiation, migration, and invasiveness into Matrigel in vitro. SD-208 also abolishes the promoting effect of TGF-β on neointimal smooth muscle-like cell (SMLC) proliferation and migration in vitro.
In vivo
SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA).
References
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