[CAS NO. 1061353-68-1] PND-1186 (VS-4718)
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PRODUCTS SPECIFICATIONS [1061353-68-1]
Store
Catalog
SLK-S7653
Brand
Selleck
CAS
1061353-68-1
DESCRIPTION [1061353-68-1]
Overview
| MDL | MFCD28125506 |
|---|---|
| Molecular Weight | 501.5 |
| Molecular Formula | C25H26F3N5O3 |
| SMILES | O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9940 mL | 9.9701 mL | 19.9402 mL |
| 5 mM | 0.3988 mL | 1.9940 mL | 3.9880 mL |
| 10 mM | 0.1994 mL | 0.9970 mL | 1.9940 mL |
| 50 mM | 0.0399 mL | 0.1994 mL | 0.3988 mL |
Description
PND-1186 (VS-4718, SR-2156) is a reversible and selective inhibitor with of 1.5 nM. PND-1186 selectively promotes tumor cell . Phase 1.
Targets
| FAK [1] (Cell-free assay) |
| 1.5 nM |
In vitro
In vitro, PND-1186 inhibits 4T1 breast carcinoma motility, promotes 4T1 apoptosis in suspended conditions, and decreases 4T1 soft agar colony number and size. In HEY and OVCAR8 cells, VS-4718 promotes G0-G1 cell-cycle arrest followed by cell death.
In vivo
In mice bearing 4T1 tumors, PND-1186 (100 mg/kg s.c.) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis. In mice bearing ID8 tumors, PND-1186 (0.5 mg/mL for p.o.) also causes ovarian carcinoma tumor growth inhibition.
References
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