[CAS NO. 936623-90-4] Sacubitril/valsartan (LCZ696)
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PRODUCTS SPECIFICATIONS [936623-90-4]
Store
Catalog
SLK-S7678
Brand
Selleck
CAS
936623-90-4
DESCRIPTION [936623-90-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 915.98 |
| Molecular Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
| SMILES | C(N([C@@H]([C@H](C)C)C(O)=O)C(CCCC)=O)C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1.C([C@H](C[C@H](C(OCC)=O)C)NC(CCC(O)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2.[NaH].O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0917 mL | 5.4586 mL | 10.9173 mL |
| 5 mM | 0.2183 mL | 1.0917 mL | 2.1835 mL |
| 10 mM | 0.1092 mL | 0.5459 mL | 1.0917 mL |
| 50 mM | 0.0218 mL | 0.1092 mL | 0.2183 mL |
Description
Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting for hypertension and heart failure. Phase 3.
Targets
| RAAS [1] |
In vivo
In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.
References
Synonyms
L-Valine, N-(1-oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1′-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
LCZ 696
Entresto
Sacubitril-valsartan mixt.
Sacubitril-valsartan
Neparvis
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