[CAS NO. 1423715-09-6] SP2509
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PRODUCTS SPECIFICATIONS [1423715-09-6]
Catalog
SLK-S7680
Brand
Selleck
CAS
1423715-09-6
DESCRIPTION [1423715-09-6]
Overview
| MDL | MFCD28348370 |
|---|---|
| Molecular Weight | 437.90 |
| Molecular Formula | C19H20ClN3O5S |
| SMILES | O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2836 mL | 11.4181 mL | 22.8363 mL |
| 5 mM | 0.4567 mL | 2.2836 mL | 4.5673 mL |
| 10 mM | 0.2284 mL | 1.1418 mL | 2.2836 mL |
| 50 mM | 0.0457 mL | 0.2284 mL | 0.4567 mL |
Description
SP2509 (HCI-2509) is a selective inhibitor with of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces and promotes .
Targets
| LSD1 [1] (Cell-free assay) |
| 13 nM |
In vitro
In AML cells, SP2509 inhibits the association of LSD1 with CoREST, increases promoter-specific H3K4Me3 and induces p53, p21 and C/EBPα. SP2509 also significantly inhibits the colony growth and induces apoptosis of OCI-AML3. In addition, SP2509 induces differentiation of cultured and primary AML cells, and exerts synergistic lethal activity when used in combination with panobinostat.
In vivo
In mice bearing OCI-AML3 xenografts, SP2509 (25 mg/kg i.p.) significantly improved the survival of the mice, while co-treatment with SP2509 and panobinostat exerts superior in vivo activity.
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